Capillary Electrophoresis of Nucleic Acids, VI, anonym.to

Capillary Electrophoresis of Nucleic Acids, VI

Date: 29 Dec 2006, 20:35

Introduction to the Capillary Electrophoresis
(Methods in Molecular Biology)
Pages: 484

An outstanding panel of hands-on experts and developers of CE equipment describe in

step-by-step fashion their best cutting-edge methods for the detection and analysis of DNA

mutations and modifications, ranging from precise DNA loci to entire genomes of organisms.

This first volume of the set, Introduction to the Capillary Electrophoresis of Nucleic

Acids, covers the practical and theoretical considerations behind the use of capillary

electrophoresis for the analysis of small oligonucleotides and modified nucleotides. Along

with detailed instructions ensuring ready reproducibility, these protocols offer

time-tested advice on instrumentation, signal detection, the capillary environment, and

the integration of mass spectrometry with CE. Several chapters are devoted to the analysis

of small therapeutic oligonucleotides, nucleosides, and ribonucleotides by CE. The

companion volume, Practical Applications of Capillary Electrophoresis, addresses

techniques for high-throughput analysis of DNA fragments using SNP detection, mutation

detection, DNA sequencing methods, and DNA–ligand interactions. Comprehensive and

up-to-date, the paired volumes of Capillary Electrophoresis of Nucleic Acids offer an

authoritative guide with easy access to fast, versatile, reliable, and powerful

technologies for all those basic and clinical investigators analyzing DNA variation today.

Part 1

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